Mr. C. J. Bond, C.M.G.

Baker’s yeast catalyzed Henry reaction: Biocatalytic C-C bond formation

The C-C bond formation is an important reaction in organic synthesis to obtain value-added intermediates. Therefore, in this paper an attempt has been made to accelerate the Henry reaction (C-C bond formation) between aryl aldehydes and nitromethane using less expensive whole cell biocatalyst, baker’s yeast (BY). The scope of the methodology was also tested for the heteryl aldehyde i.e. 2-chlor...

Baker’s yeast catalyzed Henry reaction: Biocatalytic C-C bond formation

The C-C bond formation is an important reaction in organic synthesis to obtain value-added intermediates. Therefore, in this paper an attempt has been made to accelerate the Henry reaction (C-C bond formation) between aryl aldehydes and nitromethane using less expensive whole cell biocatalyst, baker’s yeast (BY). The scope of the methodology was also tested for the heteryl aldehyde i.e. 2-chlor...

C¢H Bond Cyclometalation

Oxidation of zero-valent phosphine complexes [M(PBu3)2] (M=Pd, Pt) has been investigated in 1,2difluorobenzene solution using cyclic voltammetry and subsequently using the ferrocenium cation as a chemical redox agent. In the case of palladium, a mononuclear paramagnetic Pd derivative was readily isolated from solution and fully characterized (EPR, X-ray crystallography). While in situ electroch...

Dr. C. J. C. Earl

Exploiting the C-H bond in metal-catalyzed C-C bond-forming reactions

This account summarizes our work in the field of direct C-H bond functionalization. We have explored methods in the area of directing group assisted C(sp 2 )-H and C(sp 3 )-H activation and investigated arylation as well as deuteration reactions. In these transformations either ruthenium or palladium catalysts were applied. In case of C(sp 2 )-H activation, we developed a protocol for the synth...